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'The Number One Question You Must Ask For Canadian Pharmacies J.L. & Med. 193 (2006) (drug importation from Canada unlikely to substantively benefit U.S. Cyberpharmacies and the role of the US Food and Drug Administration. To measure the quality and usefulness of patient information leaflets distributed in Canadian pharmacies, we compared the information contained in 3 leaflets distributed in Canada for cisapride monohydrate (Prepulsid in Canada, Propulsid in the United States) with that in the leaflet approved by the US Food and Drug Administration (FDA).<br><br>The drug makers were able to restore the discounts. This makes drug makers skittish about offering discounts to Americans in need. To read more regarding [https://onlinepharmacycanadahelp.com/ erectile dysfunction medications] look at the page. For example, the Together Rx™ card, [https://www.trainingzone.co.uk/search?search_api_views_fulltext=sponsored sponsored] by seven drug companies, including Glaxo and AstraZeneca, offers saving of 20 percent to 40 percent on more than 150 medications for couples earning $38,000 (US) or less.Last October, Glaxo and one of its competitors in Together Rx™ reduced the discounts they offered, for fear that the US [https://www.exeideas.com/?s=government government] would force heavily discounted prices for other beneficiaries.<br><br>The only advice the First DataBank leaflet provides to patients is to "contact your doctor immediately" if any of a long list of adverse effects are experienced, including irregular heartbeats. The first paragraph in the FDA- approved patient information leaflet for cisapride begins as follows: "Propulsid may cause serious irregular heartbeats that may cause death." None of the 3 patient information leaflets distributed in Canada that we looked at contain a statement on potentially fatal cardiac arrhythmia, the most serious risk associated with cisapride.<br><br>Get medical help if they experience dizziness or irregular heartbeats. The FDA-approved leaflet lists 12 medical conditions for which cisapride use is contraindicated. The FDA-approved patient information leaflet for cisapride lists 21 generic names and 25 brand names for drugs whose use is contraindicated with cisapride, followed by a caution that "This is not a complete list of medications that you should not take. We looked for 5 types of information: a statement of the most serious risk associated with use of cisapride; drugs with which cisapride use is contraindicated; medical conditions with which cisapride use is contraindicated; the safety and effectiveness of the drug in children; and explicit instructions on contacting the prescriber if specific adverse effects are experienced.<br><br> None of the leaflets being distributed to Canadian patients that we assessed contained both information on the most serious risk associated with the use of the drug. The patient information leaflet from the unknown publisher lists no drugs whose use is contraindicated with cisapride. The FDA-approved patient information states that "the safety and effectiveness of Propulsid in children younger than 16 years have not been demonstrated for any use." The Janssen-Ortho patient information leaflet does indicate that cisapride should not be used in children, but no age range is given.<br><br> The other 2 patient information leaflets distributed to Canadian patients make no reference to the use of cisapride in children. Patients or their caregivers may think that the drug information leaflet is all they need in order to understand how to use a drug safely and effectively. It also gives explicit instructions on the steps a patient should take if the symptoms of cardiac toxicity develop, including stopping use of the drug immediately.'